Bousigonine A and B,bis- and tri-indole alkaloids from Bousigonia mekongensis and their preventing high glucose-induced podocyte injury activity |
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| Authors: | Ya-Lan Wang Chang-Run Guo Yan Mu Yun-Liang Lin Hui-Jiao Yan Zhi-Wei Wang Xiao-Jing Wang |
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| Affiliation: | 1. School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250200, China;2. Shandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), 19 Keyuan Street, Jinan 250014, China;3. Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan 250062, China;4. School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China |
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| Abstract: | Bousigonine A (1), an unprecedented eburnamine-voaphylline type dimeric indole alkaloid, and Bousigonine B (2), the first example of eburnamine-eburnamine-aspidospermine type trimeric indole alkaloid were isolated from Bousigonia mekongensis. Their structures were elucidated mainly by spectroscopic analysis and compared to published data. Their preventing high glucose-induced podocyte injury activity were evaluated for the first time, and compound 1 exhibited significant effect with EC50 value of 2.5 μM. |
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| Keywords: | Corresponding authors at: School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250200, China (W.-J. Wang). Indole alkaloid Diabetic nephropathy Podocyte injury |
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