Water-acetic acid mediated an efficient one-pot eco-friendly synthesis of novel bis-isoxazolopyrroloquinoline derivatives |
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Authors: | Sri Venkateswarlu Rayudu Dipankar Karmakar Pramod Kumar |
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Institution: | 1. Department of Research and Development, Seutic Pharma Private Limited, IDA, Jeedimetla, Hyderabad 500055, Telangana, India;2. Director-Chemistry Services, Novick Biosciences, Private Limited, Balanagar, Hyderabad 500037, Telangana, India;3. Centre for Chemical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad 500085, Telangana, India |
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Abstract: | An efficient, cost-effective and environmentally benign synthesis of novel tetracyclic bis-isoxazolopyrroloquinoline derivatives has been developed via one-pot four-component reaction of 4-amino-3-methyl-5-styrylisoxazoles, dimedone, aryl glyoxal monohydrates and 5-amino-3-methylisoxazole by employing water as a reaction medium and acetic acid (AcOH) as a green promoter. The advantages of this protocol are environmentally friendly, metal-free, less reaction time, operational simplicity, high yields, broad substrate scope and easy purification. Most significant of all, this method is green. |
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Keywords: | Corresponding author Bis-isoxazolopyrroloquinoline One-pot synthesis Aqueous medium Green chemistry |
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