|
|||||
|
|
Synthesis of (+)-goniopypyrone and (+)-goniotriol using Pd-catalyzed carbonylation |
|
| Authors: | Yuki Miyazawa Makoto Sugimoto Ayumi Tanaka-Oda Hidefumi Makabe |
| Institution: | 1. School of Science and Technology, Department of Agriculture, Division of Food Science and Biotechnology, Shinshu University, 8304 Minami-minowa, Kami-ina, Nagano 399-4598, Japan;2. Center for Supports to Advanced Science, Division of Instrumental Research, Shinshu University, 8304 Minami-minowa, Kami-ina, Nagano 399-4598, Japan;3. Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge, Department of Biomolecular Innovation, Shinshu University, 8304 Minami-minowa, Kami-ina, Nagano 399-4598, Japan |
| Abstract: | Syntheses of (+)-goniopypyrone and (+)-goniotriol isolated from Goniothalamus giganteus were achieved. The key steps involve Pd-catalyzed carbonylation for lactone ring formation and diastereoselective reduction of ynone using the (R)-CBS catalyst and borane dimethyl sulfide complex. |
| Keywords: | Corresponding author at: School of Science and Technology Department of Agriculture Division of Food Science and Biotechnology Shinshu University 8304 Minami-minowa Kami-ina Nagano 399-4598 Japan Natural product Polyketides Styryl lactone Carbonylation |
| 本文献已被 ScienceDirect 等数据库收录！ | |