Photoredox catalyzed C(sp3)C(sp) coupling of dihydropyridines and alkynylbenziodoxolones |
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| Authors: | Shengzong Liang Ricardo A Angnes Chinmay S Potnis Gerald B Hammond |
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| Institution: | 1. Chemistry Institute, State University of Campinas – Unicamp C.P. 6154, CEP 13083-970 Campinas, São Paulo, Brazil;2. Department of Chemistry, University of Louisville, Louisville, KY 40292, United States |
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| Abstract: | A visible light mediated deformylative alkynylation of aldehydes is presented. Under photo irradiation, 1,4-dihydropyridine (DHP), derived from an aldehyde, generated a C(sp3)- radical which couples with an alkynylbenziodoxolone to generate an alkyl substituted alkyne coupling product. This strategy is mild and easy to operate, a wide range of functional groups were tolerated, and 16 examples of products with 35–86% yields were obtained. |
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| Keywords: | Corresponding author Photoredox Alkynylbenziodoxolones Alkynylation |
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