Synthesis of All‐Carbon Quaternary Centers by Palladium‐Catalyzed Olefin Dicarbofunctionalization |
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Authors: | Maximilian Koy Peter Bellotti Felix Katzenburg Constantin G Daniliuc Frank Glorius |
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Abstract: | The redox‐neutral dicarbofunctionalization of tri‐ and tetrasubstituted olefins to form a variety of (hetero)cyclic compounds under photoinduced palladium catalysis is described. This cascade reaction process was used to couple styrenes or acryl amides with a broad range of highly decorated olefins tethered to aryl or alkyl bromides (>50 examples). This procedure enables one or two contiguous all‐carbon quaternary centers to be formed in a single step. The products could be readily diversified and applied in the synthesis of a bioactive oxindole analogue. |
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Keywords: | dicarbofunctionalization heterocycles palladium catalysis quaternary centers radicals |
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