Recent applications of mechanochemistry in enantioselective synthesis |
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Authors: | C Gabriela Avila-Ortiz Mario Pérez-Venegas Jorge Vargas-Caporali Eusebio Juaristi |
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Institution: | 1. Departamento de Química, Centro de Investigación y de Estudios Avanzados, Avenida IPN # 2508, 07360 Ciudad de México, Mexico;2. El Colegio Nacional, Donceles No. 104, Centro Histórico, 06020 Ciudad de México, Mexico |
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Abstract: | In recent years, sustainable organocatalysis has become a relevant target in asymmetric organic synthesis. Among the most successful strategies to achieve “greener” organocatalyzed processes are (1) the elimination of solvent from reaction media, and (2) the use of alternative activation energies such as solvent-free mechanochemistry in high speed ball mills. In recent years we have stepped up efforts in the pursuit of organocatalysts and biocatalysts that allow reactions to take place in the absence of solvent and under mechanochemical activation. In this article we present the application of small dipeptides as chiral organocatalysts under solvent-free and high-speed ball milling conditions, with focus on the asymmetric aldol addition reaction. Finally, we report on recent results using supported enzymes for the resolution of racemic β-amino acids and amines, under mechanochemical conditions. |
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Keywords: | Corresponding author at: Departamento de Química Centro de Investigación y de Estudios Avanzados Avenida IPN # 2508 07360 Ciudad de México Mexico Asymmetric organocatalysis Green chemistry Mechanochemistry Solvent-free reaction |
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