Euphatexols A and B,two unusual euphane triterpenoids from the latex of Euphorbia resinifera |
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Authors: | Yanru Qi Wei Liu Yu Chen Ming Guan Tao Yuan |
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Institution: | 1. College of Chemistry and Chemical Engineering, Xinjiang Normal University, Urumqi 830054, China;2. College of Life Science, Jiangxi Normal University, Nanchang 330022, China |
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Abstract: | Two unusual euphane triterpenoids, named euphatexols A (1) and B (2), were isolated from the latex of Euphorbia resinifera. Their structures were elucidated based on the extensive analysis of spectroscopic data (HRMS, 1D and 2D NMR). Compound 1 possesses a rare tetrahydrofuran ring formed via C-1 and C-11, which is firstly reported in euphane triterpenoids. Compound 2 represents an unusual 27-nor-euphane triterpenoid. Moreover, compounds 1 and 2 showed significant cytotoxic activities against HepG2 cells with 87.0% and 87.4% inhibition rate at 1 μM, respectively. |
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Keywords: | Corresponding authors Euphatexol Triterpenoids Latex |
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