A highly fluorescent adenine derivative and its interaction with iron ions |
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Authors: | Zhengzhou Liu Zheng Lu Weifeng Peng Yang Liu Jianghuai Hu Ke Zeng Gang Yang |
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Institution: | State Key Laboratory of Polymer Materials Engineering, College of Polymer Science and Engineering, Sichuan University, Chengdu, 610065, PR China |
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Abstract: | In this paper, an adenine-derived fluorescent chromophore (HCC-APA) was synthesized to detect its interaction with iron ions. The results showed that a large stokes shift (υ = 10981.5 cm?1) fluorescence of the HCC-APA was appeared. The fluorescence quantum yields of HCC-APA in DMF and THF were 3.49% and 17.54%, respectively, demonstrating its higher fluorescence performance than unmodified adenine. Besides, the fluorescence quenching of HCC-APA with iron ions was further detected. Fluorescence titration experiments confirmed that the detection limit of HCC-APA for Fe3+ was 3.69 μM. The interaction between iron ions and HCC-APA was investigated by continuous variable method, indicating that the binding ratio is 1:1. And the interaction site was deeply explored by 1H NMR and molecular simulation. |
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Keywords: | Corresponding author Adenine Fluorescence Iron ions detection Molecular simulation |
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