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Design and synthesis of A- and D ring-modified analogues of luotonin A with reduced planarity |
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| Authors: | Abdulrahman I. Almansour Raju Suresh Kumar Natarajan Arumugam Giulia Bianchini J. Carlos Menéndez Dhaifallah M. Al-thamili Govindasami Periyasami Mohammad Altaf |
| Affiliation: | 1. Department of Chemistry, College of Science, King Saud University, Riyadh, P.O. Box 2455, Riyadh 11451, Saudi Arabia;2. Unidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain;3. Central Laboratory, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia |
| Abstract: | A small library of A- and D-ring modified luotonin-inspired heterocyclic systems have been synthesised in moderate to good yields following a six-step route that starts from phenylalanine and has the final key stage an intramolecular Povarov reaction of imines obtained from a tetrahydroquinoline-derived alkynyl aldehyde and various arylamines. |
| Keywords: | Corresponding authors. Luotonin Alkaloids Anticancer compounds Nitrogen heterocycles |
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