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A copper(II)-mediated radical cross-dehydrogenative coupling/sulfinic acid elimination approach to 2-quinolones |
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| Authors: | Ryan M. Gorman Timothy E. Hurst Wade F. Petersen Richard J.K. Taylor |
| Affiliation: | Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK |
| Abstract: | A new cyclisation procedure to prepare 4-carboxy-quinolin-2-ones via a one-pot Cu(II)-mediated radical cross-dehydrogenative coupling/sulfinic acid elimination of linear anilides is described. Extensions to more complex substrates are also reported as are applications in target synthesis allowing access to natural products isolated from Oryza sativa and HOFQ. |
| Keywords: | Corresponding author. 2-Quinolones Cross-dehydrogenative coupling Cu(II)-catalysis Total synthesis |
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