Novel and simple preparation method of matrix-type composite particles for controlled drug release by mechanical action |
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Authors: | Kondo Shin-ichi Sasai Yasushi Kosaki Masato Kuzuya Masayuki |
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Institution: | Laboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University, Japan. |
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Abstract: | Matrix-type composite particle for controlled drug release can readily be prepared through a totally dry process by simple anaerobic mechanical vibration of mechanoradical-containing ethylcellulose (EC) with theophylline powder due to occurrence of collision-induced radical-radical coupling reaction to form interparticle matrices, as well as the formation of interparticle network when solid-state vinyl monomer was further added. |
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