Highly diastereoselective and enantioselective synthesis of enantiopure C2-Symmetrical vicinal diamines by reductive homocoupling of chiral N-tert-butanesulfinyl imines |
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| Authors: | Zhong Yu-Wu Izumi Kenji Xu Ming-Hua Lin Guo-Qiang |
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| Affiliation: | Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China. |
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| Abstract: | [reaction: see text] An efficient and straightforward method for the preparation of highly enantiomerically enriched C2-symmetrical vicinal diamines by the reductive homocoupling of aromatic N-tert-butanesulfinyl imines in the presence of SmI2 and HMPA was developed. It gives access to a variety of enantiopure C2-symmetrical 1,2-diamines in a very mild and practical way. |
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