| IgA肾病免疫吸附剂吸附性能及血液相容性研究 |
| |
| 引用本文： | 邢克礼,储佳强,俞耀庭.IgA肾病免疫吸附剂吸附性能及血液相容性研究[J].离子交换与吸附,2003,19(3):241-246. |
| |
| 作者姓名： | 邢克礼 储佳强 俞耀庭 |
| |
| 作者单位： | 1. 天津医科大学生物医学工程系,天津,300070
2. 南开大学分子生物所,天津,300071 |
| |
| 摘 要： | 针对IgA肾病研究制备用于IgA吸附的免疫吸附剂．采用不同活化方法、不同配基制备吸附剂，测定吸附效率并进行比较．体外吸附实验表明吸附剂对IgA肾病病人血清中的IgA具有较强的吸附性能；对正常人血液进行血液相容性实验及对健康小鼠的急性毒性实验证明该吸附剂具有良好的血液相容性且安全、无毒．该吸附剂可作为IgA肾病的免疫吸附剂．
|
| 关 键 词： | 血液净化疗法 IgA肾病 免疫吸附剂 吸附性能 血液相容性 肾小球疾病 |
| 文章编号： | 1001-5493(2003)03-0241-06 |
| 修稿时间： | 2003年3月16日 |
IMMUNOADSORBENT FOR IgA NEPHROPATHY-STUDY OF ABSORB PERFORMANCE AND HEMOCOMPATIBILITY |
| |
| XING Keli,CHU Jiaqiang,YU Yaoting.IMMUNOADSORBENT FOR IgA NEPHROPATHY-STUDY OF ABSORB PERFORMANCE AND HEMOCOMPATIBILITY[J].Ion Exchange and Adsorption,2003,19(3):241-246. |
| |
| Authors: | XING Keli CHU Jiaqiang YU Yaoting |
| |
| Institution: | XING Keli1 CHU Jiaqiang2 YU Yaoting2 1 Department of Biomedical Engineering of Tianjin Medical University,Tianjin 300070,China 2 Institute for Molecular Biology of Nankai University,Tianjin 300071,China |
| |
| Abstract: | The preparation of the immunoadsorbent used for IgA absorbing. Absorption efficiency was determined and compared, with adsorbent prepared in different active ways and different immobilized ligands. Adsorption experiment of the immunoadsorbent showed that it can remove serum IgA. Hemocompatibility and toxicity experiments showed that the immunoadsorbent had a good hemocompatibility and no toxicity. The adsorbent can be used as immunoadsorbent of IgA nephropathy. |
| |
| Keywords: | IgA nephropathy Immunoadsorbent Adsorption efficiency Hemocompatibility |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
