Gastroscopy-conjugated photoacoustic and ultrasonic dual-mode imaging for detection of submucosal gastric cancer:in vitro study |
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| Authors: | Huaqin Wu Haiyang Song Yudian Huang Zhifang Li Shulian Wu Xiaoman Zhang Hui Li |
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| Institution: | (College of Photonic and Electronic Engineering,Fujian Normal University,Fujian Provincial Engineering Research Center for OptoElectronic Sensing Technology,Fujian Provincial Key Laboratory of Photonic Technology,Key Laboratory of Optoelectronic Science and Technology for Medicine,Ministry of Education,Fuzhou 350007,China;Department of Pathology,Fuzhou First Hospital Affiliated to Fujian Medical University,Fuzhou 350009,China) |
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| Abstract: | This paper presents photoacoustic and ultrasonic dual-mode imaging for real-time detection of submucosal gastric cancer with a combination of gastroscopy. The diagnostic capacity was directly addressed via several phantoms and ex vivo experiments. Results demonstrated that superficial and submucosal gastric cancer can be diagnosed with a perceptible depth of 6.33 mm, a lateral accuracy of 2.23 mm, and a longitudinal accuracy of 0.17 mm though capturing the morphology of angiogenesis, which is a main character of the therioma-related change. The capability of gastroscopy-conjugated photoacoustic and ultrasonic dual-mode imaging system will own great potential in improving the clinical diagnostic rate of submucosal gastric cancer. |
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