A new cytotoxic cholesterol sulfate from marine sponge Halichondria rugosa |
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| Authors: | Zhang Hong-Jun Sun Jing-Bo Lin Hou-Wen Wang Zeng-Lei Tang Hua Cheng Ping Chen Wan-Sheng Yi Yang-Hua |
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| Institution: | Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200433, China. |
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| Abstract: | A new steroid, 24xi,25-dimethyl-3alpha-hydroxyl-cholest-5-ene-2beta-ol sodium sulfate (1), together with a known steroid, 24xi,25-dimethyl-cholest-5-ene-2beta,3alpha-diol disodium sulfate (2), was isolated from the ethanol extract of marine sponge Halichondria rugosa. Their structures were elucidated on the base of spectroscopic analysis. Both compounds showed cytotoxicity to four human cancer cell lines (BEL-7402, HT-29, SPC-A1 and U-251) with IC(50) values between 6.5 and 23.1 microM. |
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