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Asymmetric reduction of 2-substituted 2-butenolides with reductase from Marchantia polymorpha |
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| Authors: | Kei Shimoda Naoji Kubota |
| Institution: | Department of Pharmacology and Therapeutics, Faculty of Medicine, Oita University, 1-1 Hasama-machi, Oita 879-5593, Japan |
| Abstract: | A p68 reductase participating in the asymmetric reduction of the C–C double bond of 2-substituted 2-butenolides was isolated from Marchantia polymorpha. The enzyme reduced 2-substituted 2-butenolides to give (R)-butanolides, and the reduction of citraconic anhydride afforded (R)-methylsuccinic anhydride. |
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