| 噪声应激对大鼠免疫功能的影响 |
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| 引用本文： | 胡军祥,黄佩龙,姜玉新,杨琼霞,王炎钦. 噪声应激对大鼠免疫功能的影响[J]. 浙江大学学报(理学版), 2009, 36(2): 211-215. DOI: 10.3785/j.issn.1008-9497.2009.02.022 |
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| 作者姓名： | 胡军祥 黄佩龙 姜玉新 杨琼霞 王炎钦 |
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| 作者单位： | 1. 浙江林学院,林业与生物技术学院,浙江,临安,311300
2. 皖南医学院,生理学教研室,安徽,芜湖,241001 |
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| 基金项目： | 浙江省自然科学基金，国家自然科学基金 |
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| 摘 要： | 以SD大鼠为材料，分别给予80dB和100dB的噪声刺激，在第1、5、10、15、20d检测大鼠的免疫功能的变化，实验结果表明：机体由于噪声应激产生免疫抑制因子，导致T淋巴细胞转化和T淋巴细胞ANAE＋率显著下降；巨噬细胞的FC受体阳性百分率和对抗原的吞噬能力下降；B淋巴细胞的抗体形成及抗体效价降低，表明机体的细胞免疫、体液免疫和非特异性免疫功能下降。
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| 关 键 词： | 噪声应激 免疫功能 大鼠 |
Effects of noise stress on immune function in rats |
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| HU Jun-xiang,HUANG Pei-long,JIANG Yu-xin,YANG Qiong-xia,WANG Yan-qin. Effects of noise stress on immune function in rats[J]. Journal of Zhejiang University(Sciences Edition), 2009, 36(2): 211-215. DOI: 10.3785/j.issn.1008-9497.2009.02.022 |
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| Authors: | HU Jun-xiang HUANG Pei-long JIANG Yu-xin YANG Qiong-xia WANG Yan-qin |
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| Affiliation: | 1. College of Forestry and Biotechnology;Zhejiang Forestry University;Lin'an 311300;Zhejiang Province;China;2. Department of Physiology;Wannan Medical College;Wuhu 241001;Anhui Province;China |
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| Abstract: | Sprague Dawlay （SD） rats were used for the study. They were separately stimulated by 80 dB S11 100 dB noise, the cellular and humoral immune function were examined in 1,5,10,15,20 days. The experimental results showed owing to the producing of immune suppresive factor（ISF） in the organism, the noise stress significantly reduced the T Lymphocyte transformation and number of acid-naphthyl acetate esterase positive reaction（ANAE＋ ）T Lymphocyte, and lowered the Fragment Crystallizable receptor positive reaction （FcR＋） and phagocytosis of macrophage for the antigen, and decreased the antibody formation and antibody titer of B lymphocytes. These showed the decreasing function of cellular, hormoral and non-specifical immune in rats. |
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| Keywords: | noise stress immune function rats |
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