Hypervalent organochalcogenanes as inhibitors of protein tyrosine phosphatases |
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Authors: | Piovan Leandro Wu Li Zhang Zhong-Yin Andrade Leandro H |
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Institution: | Instituto de Química, Universidade de S?o Paulo, Av. Prof. Lineu Prestes 748, SP 05508-900, S?o Paulo, Brazil. |
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Abstract: | A series of organochalcogenanes was synthesized and evaluated as protein tyrosine phosphatases (PTPs) inhibitors. The results indicate that organochalcogenanes inactivate the PTPs in a time- and concentration-dependent fashion, most likely through covalent modification of the active site sulfur-moiety by the chalcogen atom. Consequently, organochalcogenanes represent a new class of mechanism-based probes to modulate the PTP-mediated cellular processes. |
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