| 由(S)-和( R )-天冬氨酸合成( R )-和(S)-(2-苄氧乙基)环氧乙烷的改良方法 |
| |
| 引用本文： | 张合胜.由(S)-和( R )-天冬氨酸合成( R )-和(S)-(2-苄氧乙基)环氧乙烷的改良方法[J].应用化学,2002,19(3):304-0. |
| |
| 作者姓名： | 张合胜 |
| |
| 作者单位： | 1. 湖北大学化学与材料科学学院,武汉,430062,澳大利亚昆士兰大学化学系,布里斯班,4072,澳大利亚
2. 澳大利亚昆士兰大学化学系,布里斯班,4072,澳大利亚 |
| |
| 摘 要： | 苄氧乙基环氧乙烷;不对称合成;由(S)-和( R )-天冬氨酸合成( R )-和(S)-(2-苄氧乙基)环氧乙烷的改良方法
|
| 关 键 词： | 苄氧乙基环氧乙烷 不对称合成 由(S)-和( R )-天冬氨酸合成( R )-和(S)-(2-苄氧乙基)环氧乙烷的改良方法 |
| 文章编号： | 1000-0518(2002)03-0304-03 |
| 收稿时间： | 2009-06-29 |
| 修稿时间： | 2001年6月15日 |
A Modified Synthesis of (R)- and (S)-(2-Benzyloxyethyl)oxirane from (S)- and (R)-Aspartic Acid |
| |
| William Kitching.A Modified Synthesis of (R)- and (S)-(2-Benzyloxyethyl)oxirane from (S)- and (R)-Aspartic Acid[J].Chinese Journal of Applied Chemistry,2002,19(3):304-0. |
| |
| Authors: | William Kitching |
| |
| Abstract: | R ) and ( S ) (2 benzyloxyethyl)oxirane 1 were prepared from ( S ) and ( R ) aspartic acid by modification of the procedure described by Rapoport. Aspartic acid was converted into bromosuccinic acid 2 by treatment with sodium nitrite/potassium bromide/sulfuric acid,the diacid 2 was then reduced with freshly prepared boron trifluoride ethyl ether complex to bromodiol 3, which was further treated with sodium hydride and benzylbromide/TBAI(tetrabutylammonium iodide) to afford (2 benzyloxyethyl)oxirane. This procedure has shown the good yield, mild condition and excellent enantiomeric purity of the product. |
| |
| Keywords: | benzyloxyethyl)oxirane aspartic acid asymmetric synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《应用化学》浏览原始摘要信息 |
| 点击此处可从《应用化学》下载免费的PDF全文 |
