Synthetic methods for polyamine linkers and their application to combinatorial chemistry |
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Authors: | Ian R. Marsh Helen K. Smith Catherine Leblanc Mark Bradley |
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Affiliation: | (1) Department of Chemistry, University of Southampton, SO17 1BJ Highfield, Southampton, UK |
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Abstract: | Summary Polyamines and polyamine conjugates display a diverse range of important biological functions, ranging from antibiotics to immunosuppressants and glutamate receptor antagonists. For these reasons, polyamines provide an excellent template/scaffold for combinatorial chemistry. In this paper we present methods for the solid-phase immobilisation of polyamines for use in synthetic and combinatorial chemistry and describe how they have been employed in the preparation of a number of important polyamine conjugates and polyamine libraries. Thus, we have designed, synthesised and utilised a number of polyamine linkers for both solution and resin screening combinatorial application. |
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Keywords: | Polyamines Solid phase Combinatorial Library Urethane linker |
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