Stochastic resonant signaling in enzyme cascades |
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Authors: | Lan Yueheng Papoian Garegin A |
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Institution: | Department of Chemistry, University of North Carolina at Chapel Hill, North Carolina 27599-3290, USA. |
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Abstract: | We observe the phenomenon of stochastic resonant signaling in signal amplification enzyme cascades, where certain optimal reaction rates minimize the average threshold-crossing time. We develop a new analytical technique to obtain the mean first passage time, based on a novel decomposition of the master equation. Our analytical results are in good agreement with the exact numerical simulations. We demonstrate that resonant behavior may be a ubiquitous phenomenon in stochastic threshold crossing in cell signaling. The physical principles behind this phenomenon are elucidated. |
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