The Potential of Micellar Media in the Synthesis of DNA-Encoded Libraries |
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Authors: | Réka Adamik Dr Balázs Buchholcz Dr Ferenc Darvas Dr Gellért Sipos Dr Zoltán Novák |
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Institution: | 1. ELTE “Lendület” Catalysis and Organic Synthesis Research Group, Institute of Chemistry, Eötvös Loránd University, Pázmány Péter stny. 1/A, 1117 Budapest, Hungary;2. Innostudio Inc., Záhony u. 7, 1031 Budapest, Hungary;3. ComInnex Inc., Záhony u. 7, 1031 Budapest, Hungary |
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Abstract: | DNA-encoded library (DEL) technology has become widely used in drug discovery research. The construction of DELs requires robust organic transformations that proceed in aqueous media under mild conditions. Unfortunately, the application of water as reaction medium for organic synthesis is not evident due to the generally limited solubility of organic reagents. However, the use of surfactants can offer a solution to this issue. Oil-in-water microemulsions formed by surfactant micelles are able to localize hydrophobic reagents inside them, resulting in high local concentrations of the organic substances in an otherwise poorly solvated environment. This review provides a conceptual and critical summary of micellar synthesis possibilities that are well suited to DEL synthesis. Existing examples of micellar DEL approaches, together with a selection of micellar organic transformations fundamentally suitable for DEL are discussed. |
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Keywords: | catalysis DNA micelles transition metals water |
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