Three-in-One: Miniature Models of Natural Acyl-Transfer Systems Enable Vector-Selective Reaction on the Primary Side of Cyclodextrins |
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| Authors: | Tatsuro Tominaga Koki Fukuda Dr. Kazutaka Koga Dr. Makoto Fukudome Prof. Dr. De-Qi Yuan |
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| Affiliation: | 1. Department of Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Kobe Gakuin University, 1-1-3 Minatojima, Chuoku, Kobe, 650-8586 Japan;2. Department of Kampo Pharmacy, Faculty of Pharmacy, Daiichi University of Pharmacy, 22-1 Tamagawa-machi, Minami-ku, Fukuoka, 815-8511 Japan |
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| Abstract: | Miniature models of acyl-transfer systems in cells, which were composed by replacing the protein, coenzyme, and substrate with CD, functional group, and CD, respectively, and combining them all together in one, displayed definite role-sharing and exact cooperation of the functional groups and hydrophobic cavity, and thus enabled the regio-specific reaction. |
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| Keywords: | biomimetics cyclodextrins host-guest chemistry selective reactions |
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