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Laser Desorption/Ionization Mass Spectrometry Imaging: A New Tool to See through Nanoscale Particles in Biological Systems |
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| Authors: | Dr. Yuming Jiang Dr. Jie Sun Dr. Xiaohua Cao Dr. Huihui Liu Dr. Caiqiao Xiong Prof. Zongxiu Nie |
| Affiliation: | 1. College of Chemical Engineering, Jiujiang University, Jiujiang, Jiangxi Province, 332005 P.R. China Beijing National Laboratory for Molecular Sciences, Key Laboratory for Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190 P.R. China University of CAS, Beijing, 100049 P.R. China;2. Beijing National Laboratory for Molecular Sciences, Key Laboratory for Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190 P.R. China;3. College of Chemical Engineering, Jiujiang University, Jiujiang, Jiangxi Province, 332005 P.R. China |
| Abstract: | Understanding the fate of nanoscale particles (NPs) in biological systems is significant with the increasing risk for human exposure. Recent research endeavors in laser desorption/ionization mass spectrometry imaging (LDI-MSI) have enriched the toolbox for evaluation of NPs’ behavior in biological tissues, especially in aspects including sub-organ bio-distribution, clearance, quantification and surface chemistry variation analysis. In recognition of the potential for advancement in LDI MSI, this concept provides a brief overview of recent research works in LDI MSI for NPs, illustrates new applications that demonstrate the superiority of this technique, and highlights a series of perspectives and directions to move the field forward. |
| Keywords: | biological systems laser desorption mass spectrometry imaging nanoscale particles |