Palladium-Catalyzed Arylfluorination of Alkenes: A Powerful New Approach to Organofluorine Compounds |
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| Authors: | Dr Attila Márió Remete Dr Melinda Nonn Prof Loránd Kiss |
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| Institution: | 1. Institute of Pharmaceutical Chemistry, University of Szeged, 6720 Szeged, Eötvös u. 6, Hungary;2. MTA TTK Lendület Artificial Transporter Research Group, Institute of Materials and Environmental Chemistry, Research Center for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok krt. 2, 1117 Budapest, Hungary;3. Institute of Organic Chemistry, Stereochemistry Research Group, Research Centre for Natural Sciences, 1117 Budapest, Magyar tudósok krt. 2, Hungary |
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| Abstract: | Fluorine incorporation into organic molecules is often beneficial to their absorption, distribution, metabolism, and excretion (ADME) properties or bioactivity. As a consequence, organofluorine compounds have become quite common amongst drugs and agrochemicals, and their preparation is a highly important topic in both synthetic organic chemistry and pharmaceutical chemistry. One of the newly developed methods for accessing organofluorine compounds is Pd-catalyzed arylfluorination of alkenes. It is an olefin difunctionalization process that simultaneously introduces an aryl group and a fluorine atom into an alkene framework. This review provides a concise overview of this powerful and versatile method. |
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| Keywords: | arylfluorination drug research fluorination olefin difunctionalization palladium catalysis |
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