Copper-Catalyzed Direct Perfluoroalkylation of Heteroarenes |
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Authors: | Hajar Baguia Prof. Gwilherm Evano |
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Affiliation: | Laboratoire de Chimie Organique Service de Chimie et Physic Chimie Organiques, Université libre de Bruxelles (ULB), Avenue F. D. Roosevelt 50, CP160/06 1050 Brussels, Belgium |
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Abstract: | An efficient and broadly applicable process is reported for the copper-catalyzed direct perfluoroalkylation of C−H bonds in heteroarenes with commercially available perfluoroalkyl iodides. This reaction is based on a simple combination of copper(I) iodide and 1,10-phenanthroline enabling the easy reduction of perfluoroalkyl iodides to the corresponding radical species that add to a wide range of heteroarenes including benzofurans, benzothiophenes, (aza)indoles, furans and pyrroles. High levels of regioselectivity were obtained in all cases and the efficiency and robustness of this process was highlighted by the direct perfluoroalkylation of furan-containing peptides. |
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Keywords: | C−H functionalization copper-catalysis heteroarenes perfluoroalkylation radical chemistry |
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