NIR-II Fluorescent Probe for Detecting Trimethylamine Based on Intermolecular Charge Transfer |
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| Authors: | Shuai Zhao Manman Xu Ruixin Liu Yonggan Xue Prof. Jun Nie Prof. Yincheng Chang |
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| Affiliation: | 1. Beijing Laboratory of Biomedical Materials, State Key Laboratory of Chemical Resource Engineering, Changzhou Institute of Advanced Materials, Beijing University of Chemical Technology, 100029 Beijing, P. R. China;2. Department of Oncology, Guang' anmen Hospital, China Academy of Chinese Medical Sciences, 100053 Beijing, P. R. China;3. Department of General Surgery, Chinese PLA General Hospital, 100053 Beijing, P. R. China |
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| Abstract: | A new kind of small organic NIR-II fluorophore molecule (ZS-1010) based on intermolecular charge transfer was developed as a NIR-II fluorescent probe for trimethylamine (TMA) detection, which is important for the diagnosis of cardiovascular disease, chronic kidney disease and diabetes. ZS-1010 has a strong push–pull electron system composed of electron donor unit and electron acceptor unit, exhibiting strong absorption and emission in the NIR-II region. When mixed with TMA which possesses strong electron-donating characteristics, the push–pull system of ZS-1010 will be affected along with the dipole moment change, leading to the quenching of fluorescence. This is the first example of TMA fluorescent probe in the NIR-II window showing deep penetration, fast response speed, high selectivity and pH stability. |
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| Keywords: | charge transfer fluorescent probe near infrared II trimethylamine |
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