A Highly Water- and Air-Stable Iron-Containing MRI Contrast Agent Sensor for H2O2 |
| |
| Authors: | Sana Karbalaei Dr Alicja Franke Aubree Jordan Cayla Rose Dr P Raj Pokkuluri Dr Ronald J Beyers Dr Achim Zahl Prof Ivana Ivanović-Burmazović Prof Christian R Goldsmith |
| |
| Institution: | 1. Department of Chemistry and Biochemistry, Auburn University, Auburn, AL 36849 USA;2. Department of Chemistry, Ludwig-Maximilians-Universität München, 81377 München, Germany;3. Auburn University Magnetic Resonance Imaging Research Center, Auburn, AL 36849 USA;4. Department of Chemistry and Pharmacy, Friedrich-Alexander University Erlangen-Nuremberg, 91058 Erlangen, Germany |
| |
| Abstract: | A highly water- and air-stable Fe(II) complex with the quinol-containing macrocyclic ligand H4qp4 reacts with H2O2 to yield Fe(III) complexes with less highly chelating forms of the ligand that have either one or two para-quinones. The reaction increases the T1-weighted relaxivity over four-fold, enabling the complex to detect H2O2 using clinical MRI technology. The iron-containing sensor differs from its recently characterized manganese analog, which also detects H2O2, in that it is the oxidation of the metal center, rather than the ligand, that primarily enhances the relaxivity. |
| |
| Keywords: | iron magnetic resonance imaging reactive oxygen species redox sensors |
|
|
