A Catalyst and Solvent Free Route for the Synthesis of N-Substituted Pyrrolidones from Levulinic Acid |
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Authors: | Pritam Dolui Vikas Tiwari Parul Saini Dr Tarak Karmakar Koushik Makhal Harshita Goel Dr Anil J Elias |
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Institution: | Department of Chemistry, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi, 110016 India |
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Abstract: | An efficient, metal-free, catalyst-free and solvent-free methodology for the reductive amination of levulinic acid with different anilines has been developed using HBpin as the reducing reagent. This protocol offers an excellent method to avoid solvents and added catalysts on the synthesis of different kinds of N-substituted pyrrolidones under metal free conditions. It is also the first report for the synthesis of different pyrrolidones by solvent-free as well as catalyst-free methods. The proposed mechanism for the formation of pyrrolidone has been supported by DFT calculations and control experiments. |
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Keywords: | catalyst-free? levulinic acid pyrrolidones? reductive amination? solvent-free |
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