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Brookhart's Acid-Catalyzed Switchable Regioselective N-Alkylation of Arylamines/Heterocyclic Amines with Cyclopropylcarbinols by Temperature Regulation
Authors:Naveen Yadav  Aparna Tyagi  Jabir Khan  Chinmoy Kumar Hazra
Institution:1. Department of Chemistry, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016 India;2. Department of Chemistry, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016 India

Department of Chemistry, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016 India

These authors contributed equally to this work.

Abstract:An unprecedented, Brookhart's acid-catalyzed temperature-switchable regioselective divergent approach for N-alkylation of arylamines and heterocyclic amines by utilising cyclopropylcarbinols is presented herein. The reaction offers N-alkylated cyclopropyl derivatives and homoallyl amines by employing 2.5 mol% catalyst loading at different temperatures in excellent regioselectivity and yields. This method has shown to be relevant with a wide range of cyclopropylcarbinols, including aliphatic ones. Several control experiments and spectroscopic studies have been performed to gain insight into the reaction mechanism. Further, the synthetic utility of the protocol has also been described.
Keywords:alkylation  Brookhart's acids  cyclopropylcarbinol  alkylation  regioselectivity  temperature control
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