A Reversibly Porous Supramolecular Peptide Framework** |
| |
| Authors: | Dominic F. Brightwell Giada Truccolo Dr. Kushal Samanta Elliott J. Fenn Prof. Simon J. Holder Dr. Helena J. Shepherd Dr. Chris S. Hawes Dr. Aniello Palma |
| |
| Affiliation: | 1. Supramolecular Interfacial and Synthetic Chemistry Group, School of Physical Sciences, Ingram Building, University of Kent, CT2 7NH Canterbury, UK;2. School of Chemical and Physical Sciences, Lennard-Jones Building, Keele University, ST5 5BG Staffordshire, UK |
| |
| Abstract: | The ability to use bio-inspired building blocks in the assembly of novel supramolecular frameworks is at the forefront of an exciting research field. Herein, we present the first polyproline helix to self-assemble into a reversibly porous, crystalline, supramolecular peptide framework (SPF). This framework is assembled from a short oligoproline, adopting the polyproline II conformation, driven by hydrogen-bonding and dispersion interactions. Thermal activation, guest-induced dynamic porosity and enantioselective guest inclusion have been demonstrated for this novel system. The principles of the self-assembly associated with this SPF will be used as a blueprint allowing for the further development of helical peptide linkers in the rational design of SPFs and metal-peptide frameworks. |
| |
| Keywords: | enantioselectivity helical structures host–guest systems peptides polyproline supramolecular chemistry |
|
|
