|
|||||
|
|
BBr3-Mediated P(III)-Directed C?H Borylation of Phosphines |
|
| Authors: | Dr Jiahang Lv Dr Xue-Jun Zhang Prof?Dr Minyan Wang Dr Yue Zhao Prof?Dr Zhuangzhi Shi |
| Institution: | 1. State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093 P. R. China
These authors contributed equally to this work.;2. State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093 P. R. China Department of Orthopedic Surgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210093 P. R. China These authors contributed equally to this work.;3. State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093 P. R. China |
| Abstract: | Transition-metal-catalyzed C?H borylation has been widely used in the preparation of organoboron compounds. Here, we developed a general protocol on metal-free P(III)-directed C?H borylation of phosphines mediated by BBr3, resulting in the formation of products bearing both phosphorus and boron. The development of the metal-free strategy to mimic previous metallic processes has shown low cost, superior practicality, and environmental friendliness. Density functional theory (DFT) calculations demonstrate the preferred pathway for this metal-free directed C?H borylation process. |
| Keywords: | C?H borylation DFT calculation metal-free phosphines site-selectivity |