Direct Addition of Grignard Reagents to Aliphatic Carboxylic Acids Enabled by Bulky turbo-Organomagnesium Anilides |
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Authors: | Dr Kilian Colas A Catarina V D dos Santos Dr Stefanie V Kohlhepp Dr Abraham Mendoza |
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Institution: | Dept. of Organic Chemistry, Stockholm University, Arrhenius Laboratory, 106 91 Stockholm, Sweden |
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Abstract: | The synthesis of ketones through addition of organometallic reagents to aliphatic carboxylic acids is a straightforward strategy that is limited to organolithium reagents. More desirable Grignard reagents can be activated and controlled with a bulky aniline-derived turbo-Hauser base. This operationally simple procedure allows the straightforward preparation of a variety of aliphatic and perfluoroalkyl ketones alike from functionalized alkyl, aryl and heteroaryl Grignard reagents. |
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Keywords: | Magnesium ketones acylation metalation Grignard reaction |
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