| Ca(NO3)2•4H2O-catalysed Biginelli Reaction: One-pot Synthesis of 1,2,3,4-Tetrahydropyrimidin-2-ones/pyrimidine-2-thiones under Solvent-free Conditions |
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| 作者姓名： | DEBACHE Abdelmadjid BOULCINA Raouf TAFER Radia BELFAITAH Ali RHOUATI Salah CARBONI Bertrand |
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| 作者单位： | Laboratoire des Produits Naturels d’origine Végétale et de Synthèse Organique, Département de Chimie, ; Faculté des Sciences, Université Mentouri de Constantine 25000 Constantine, Algérie ; Sciences Chimiques de Rennes, UMR 6226 CNRS-Université de Rennes 1, Campus de Beaulieu, ;Université de Rennes I 35042 Rennes cedex, France ; |
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| 摘 要： | The synthesis of 1,2,3,4-dihydropyrimidinone/thione derivatives was achieved in good to excellent yields using calcium(II) nitrate as catalyst to promote the Biginelli three-component condensation reaction from a diversity of aromatic aldehydes, β-keto compounds and urea or thiourea. The reaction was carried out under solvent-free conditions.
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| 关 键 词： | Biginelli reaction 1 2 3 4-tetrahydropyrimidin-2-(1H)-one/pyrimidine-2-thione calcium(II) nitrate one-pot condensation |
| 收稿时间： | 2008-4-11 |
| 修稿时间： | 2008-5-9 |
Ca(NO3)2·4H2O‐catalysed Biginelli Reaction: One‐pot Synthesis of 1,2,3,4‐Tetrahydropyrimidin‐2‐ones/pyrimidine‐2‐thiones under Solvent‐free Conditions |
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| DEBACHE Abdelmadjid,BOULCINA Raouf,TAFER Radia,BELFAITAH Ali,RHOUATI Salah,CARBONI Bertrand.Ca(NO3)2•4H2O-catalysed Biginelli Reaction: One-pot Synthesis of 1,2,3,4-Tetrahydropyrimidin-2-ones/pyrimidine-2-thiones under Solvent-free Conditions[J].Chinese Journal of Chemistry,2008,26(11):2112-2116. |
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| Authors: | Abdelmadjid DEBACHE Raouf BOULCINA Radia TAFER Ali BELFAITAH Salah RHOUATI Bertrand CARBONI |
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| Institution: | 1. Tel./Fax: 00 213 31 81 88 62;2. Laboratoire des Produits Naturels d'origine Végétale et de Synthèse Organique, Département de Chimie, Faculté des Sciences, Université Mentouri de Constantine 25000 Constantine, Algérie;3. Sciences Chimiques de Rennes, UMR 6226 CNRS‐Université de Rennes 1, Campus de Beaulieu, Université de Rennes I 35042 Rennes cedex, France |
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| Abstract: | |
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| Keywords: | Biginelli reaction 1 2 3 4‐tetrahydropyrimidin‐2‐(1H)‐one/pyrimidine‐2‐thione calcium(II) nitrate one‐pot condensation |
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