| Synthesis of Novel Quinazoline Derivatives as Antimicrobial Agents |
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| 作者姓名： | ALY，A.A |
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| 作者单位： | DepartmentofChemistry,FacultyofScience,BenhaUniversity,Benha,Egypt |
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| 摘 要： | Quinazoline isothiocyanate 1 reacts with various nucleophiles(nitrogen nucleophiles,oxygen nucleophiles and sulphur nucleophiles)to afford heterocyclic systemes 2-13,Also,the 4 2] cycloaddition reaction of 1 with phenyl isocyanate,benzylidene aryl amine and cinnamic acid derivatives gave novel heterocyclic compounds 14-16,Moreover,the reaction of 1 with active methylene compounds under Michael reaction conditions also was investigated to yield 17 and 18 and it was found that all these reactions proceede via isothiocyanate heterocyclization to furnish non-condensed heterocyclic compoundes,Some of the newly synthesized compounds were tested for their antimicrobial activities.
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| 关 键 词： | 抗菌药 合成 抗菌活性 喹唑啉衍生物 喹唑啉异硫氰酸盐 |
Synthesis of Novel Quinazoline Derivatives as Antimicrobial Agents |
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| A. A. Aly.Synthesis of Novel Quinazoline Derivatives as Antimicrobial Agents[J].Chinese Journal of Chemistry,2003,21(3):339-346. |
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| Authors: | A A Aly |
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| Abstract: | Quinazoline isothiocyanate 1 reacts with various nucleophiles (nitrogen nucleophiles, oxygen nucleophiles and sulphur nucleophiles) to afford heterocyclic systemes 2–13. Also, the 4 + 2] cycloaddition reaction of 1 with phenyl isocyanate, benzylidene aryl amine and cinnamic acid derivatives gave novel heterocyclic compounds 14–16. Moreover, the reaction of 1 with active methylene compounds under Michael reaction conditions also was investigated to yield 17 and 18 and it was found that all these reactions proceeded via isothiocyanate heterocyclization to furnish non‐condensed heterocyclic compounds. Some of the newly synthesized compounds were tested for their antimicrobial activities. |
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| Keywords: | quinazoline congeners quinazoline isothiocyanate antimicrobial activity |
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