Synthesis of furano-epothilone D |
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| Authors: | Schinzer Dieter Bourguet Erika Ducki Sylvie |
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| Affiliation: | Chemisches Institut der Otto-von-Guericke-Universit?t, Universit?tsplatz 2, 39106 Magdeburg, Germany. Dieter.Schinzer@vst.uni-magdeburg.de |
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| Abstract: | The total synthesis of furano-epothilone D by a convergent route is reported. The key fragments are available on a large scale to provide sufficient material for biological evaluation. The approach involves a palladium-catalyzed coupling that generates a highly functionalized aldehyde which is connected in a stereoselective aldol reaction to yield the framework of furano-epothilone D. Finally, a macrolactonization provides furano-epothilone D. |
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| Keywords: | aldol reactions antitumor agents epothilone analogues macrolides natural products |
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