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Synthesis of stereoisomeric 4-(2-methylindolin-1-yl)- and 4-(2-methylindol-1-yl) derivatives of glutamic acid |
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| Authors: | Krasnov V. P. Vigorov A. Yu. Nizova I. A. Grishakov A. N. Evstigneeva N. G. Kodess M. I. |
| Affiliation: | (1) I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 20 ul. S. Kovalevskoi, 620219 Ekaterinburg, Russian Federation, Russia |
| Abstract: | The reaction of dimethyl (2S,4RS)-N-phthaloyl-4-bromoglutamate with 2-methylindoline afforded diastereomeric 4-(2-methylindolin-1-yl)-(S)-glutamic acid derivatives, whose oxidation gave rise to 4-(2-methylindol-1-yl)-(S)-glutamic acid derivatives. |
| Keywords: | glutamic acid 2-methylindoline 2-methylindole nucleophilic substitution stereoisomers |
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