| 羧基功能化离子液体催化合成1,5-苯并二氮衍生物 |
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| 引用本文： | 张薇,万树一,宫敬,宋溪明. 羧基功能化离子液体催化合成1,5-苯并二氮衍生物[J]. 合成化学, 2009, 17(6) |
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| 作者姓名： | 张薇 万树一 宫敬 宋溪明 |
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| 作者单位： | 辽宁大学,化学院,辽宁,沈阳,110036;辽宁大学,化学院,辽宁,沈阳,110036;辽宁大学,化学院,辽宁,沈阳,110036;辽宁大学,化学院,辽宁,沈阳,110036 |
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| 基金项目： | 辽宁省教育厅科研基金资助项目，辽宁大学2008年度青年科研基金 |
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| 摘 要： | 在无溶剂条件下,以邻苯二胺和丙酮为原料,羧基功能化离子液体CmmimBF_4(IL)为催化剂,合成了1,5-苯并二氮衍生物(2),其结构经~1H NMR和IR表征.在IL用量为10 mol%,于40 ℃反应1.5 h的条件下,2的产率达93%.IL无需再生处理,可连续循环使用5次,且活性无明显下降.
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| 关 键 词： | 苯并二氮衍生物 羧基功能化离子液体 催化 合成 |
Catalytic Synthesis of 1,5-Benzodiazepine Derivative by Carboxyl-functionalized Ionic Liquid |
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| ZHANG Wei,WAN Shu-yi,GONG Jing,SONG Xi-ming. Catalytic Synthesis of 1,5-Benzodiazepine Derivative by Carboxyl-functionalized Ionic Liquid[J]. Chinese Journal of Synthetic Chemistry, 2009, 17(6) |
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| Authors: | ZHANG Wei WAN Shu-yi GONG Jing SONG Xi-ming |
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| Abstract: | Using a carboxyl-functionalized ionic liquid[CmmimBF_4(IL)] as a novel reusable catalyst, 1,5-benzodiazepine derivative(2) was synthesized by the condensation of o-phenylenediamine with acetone in the absence of solvent. The yield of 2 was 93% at the reaction conditions of 10 mol% IL and at 40 ℃ for 1.5 h. IL can be reused five times continuously without a significant decrease in activity. The structure was characterized by ~1H NMR and IR. |
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| Keywords: | 1,5-benzodiazepine derivative carboxyl-functionalized ionic liquid catalyst synthesis |
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