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傅里叶变换红外光谱法用于体表无创性检测乳腺肿瘤的研究
引用本文:李庆波,徐智,徐怡庄,张元福,张能维,王立新,孙学军,张莉,王凡,杨丽敏,赵莹,任予,刘智,翁诗甫,周维金,吴瑾光.傅里叶变换红外光谱法用于体表无创性检测乳腺肿瘤的研究[J].高等学校化学学报,2004,25(11):2010-2012.
作者姓名:李庆波  徐智  徐怡庄  张元福  张能维  王立新  孙学军  张莉  王凡  杨丽敏  赵莹  任予  刘智  翁诗甫  周维金  吴瑾光
作者单位:1. 北京大学化学与分子工程学院, 稀土材料化学及应用国家重点实验室, 北京100871; 2. 北京大学第三医院, 北京100083; 3. 西安交通大学第一医院, 西安710061; 4. 中国科学院化学研究所, 北京100080
基金项目:国家重点基础研究发展规划项目(批准号:2002CCA01900),国家自然科学基金(批准号:30371604,50203001,20171004),教育部博士学科点基金资助.
摘    要:乳腺肿瘤是女性常见的疾病之一,其中乳腺癌的发病率在女性恶性肿瘤中占首位,并且发病率呈不断增加的趋势,严重危害妇女的身体健康.乳腺癌的早期诊断和治疗是提高乳腺癌患者整体生存率的关键.目前大多采用传统的X线、超声、CT和核磁共振等技术进行影像诊断,这些诊断方法需要等到肿块形成具有占位效应时才能检测出来.而振动光谱法是分子结构变化的灵敏探针,它在癌症形成的初级阶段即可观察到分子结构的改变,因此傅里叶变换中红外光谱技术有可能发展成为一种无损伤、快速和方便的肿瘤早期诊断方法.

关 键 词:FTIR  中红外光纤  乳腺肿瘤  在体原位无创检测  
文章编号:0251-0790(2004)11-2010-03
收稿时间:2004-05-21

Application of Fourier Transform Infrared Spectroscopy to Non-invasive Detection of Breast Tumor in vivo and in situ
LI Qing-Bo,XU Zhi,XU Yi-Zhuang ,ZHANG Yuan-Fu,ZHANG Neng-Wei WANG Li-Xin,SUN Xue-Jun,ZHANG Li,WANG Fan,YANG Li-Min,ZHAO Ying REN Yu,LIU Zhi,WENG Shi-Fu,ZHOU Wei-Jin,WU Jin-Guang.Application of Fourier Transform Infrared Spectroscopy to Non-invasive Detection of Breast Tumor in vivo and in situ[J].Chemical Research In Chinese Universities,2004,25(11):2010-2012.
Authors:LI Qing-Bo  XU Zhi  XU Yi-Zhuang  ZHANG Yuan-Fu  ZHANG Neng-Wei WANG Li-Xin  SUN Xue-Jun  ZHANG Li  WANG Fan  YANG Li-Min  ZHAO Ying REN Yu  LIU Zhi  WENG Shi-Fu  ZHOU Wei-Jin  WU Jin-Guang
Institution:1. The State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China; 2. The Third Hospital, Peking University, Beijing 100083, China; 3. The First Hospital of Xi′an Jiaotong University, Xi′an 710061, China; 4. Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China
Abstract:The non-invasive detection of breast tumor in vivo and in situ was first investigated by FTIR fiber optics technique. The experiment result indicates that there are significant differences between the spectra of skin outside breast tumor and normal breast tissues in the peak position and relative intensity. The in vivo FTIR spectroscopy can provide the information concerning whether the suspected tissue is cancerous or not. This recent result means that in situ FTIR spectroscopic method with fiber optics can be developed as a non-invasive, rapid and in vivo technique for early breast tumor detection.
Keywords:FTIR  Mid-IR fiber optics  Breast tumor  Non-invasive detection in vivo and in situ
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