Development and validation of a repharsed phase- HPLC method for simultaneous determination of rosiglitazone and glimepiride in combined dosage forms and human plasma |
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| Authors: | Nahed M El-Enany Amina A Abdelal Fathalla F Belal Yoshinori I Itoh Mitsuhiro N Nakamura |
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| Institution: | (1) Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, 35516, Egypt;(2) Department of Pharmacy, Gifu University Hospital, 1-1 Yanagido, Gifu 501-1194, Japan |
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| Abstract: | Background Rosiglitazone (ROZ) and glimepiride (GLM) are antidiabetic agents used in the treatment of type 2 diabetes mellitus. A survey
of the literature reveals that only one spectrophotometric method has been reported for the simultaneous determination of
ROS and GLM in pharmaceutical preparations. However the reported method suffers from the low sensitivity, for this reason,
our target was to develop a simple sensitive HPLC method for the simultaneous determination of ROZ and GLM in their combined
dosage forms and plasma. |
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