2-芳基硫杂脯氨酸结构特征的研究

对12种2-芳基硫杂脯氨酸进行了红外光谱和核磁共振谱测定,对其中两个化合物作了质谱测定。结果表明,这类化合物固态时主要以两性离子形式存在;有较强的分子离子峰,是一类较稳定的化合物。它们还存在一对非对映异构体,芳环上的取代基对芳环电子云密度的影响较大,而对四氢噻唑环的影响较小。

THE STRUCTURAL CHARACTERISTICS OF 2-ARYL-THIAZOLIDINE-4-CARBOXYLIC ACIDS

IR and NMR spectra of some 2-aryl-thiazolidine-4-carboxyli acids and MS spectra oftwo of them have been recorded. As indicated by IR, the 2-aryl-thiazolidine-4-carboxylicocids in solid state mainly exist in the zwitterion form. These compounds are rather stableand a considerable similarity among them in cleavage were found in MS spectra. The NMRspectra revealed the existence of diasteroisomers for these compounds and the influence ofthe substituents on the electron density of the carbon atoms of the benzere ring is muchgreater than on that of the thiazolidine ring.