Facile synthesis of 2,3,5,6-tetrabromo-4-methyl-nitrocyclohexa-2,5-dien-1-one, a mild nitration reagent |
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Authors: | Arnatt Christopher K Zhang Yan |
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Affiliation: | Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 2329, USA, ; Tel: 804-828-7625. |
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Abstract: | Nitrocylcohexadienones have been applied as nitration reagents for mild, mono-nitrating reactions. The original synthesis of 2,3,5,6-tetrabromo-4-methyl-4-nitrocylcohexa-2,5-dien-1-one appeared to be difficult to pursue due to both the solvent system and reaction conditions. Therefore, we applied a modified solvent system and optimized the reaction conditions to prepare the dienone at 0°C, eventually overcome the difficulties. |
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