Synthesis of novel molecular probes inspired by harringtonolide |
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Authors: | Hegde Vinayak Campitelli Marc Quinn Ronald J Camp David |
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Affiliation: | Eskitis Institute, Griffith University, Nathan, QLD 4111, Australia. |
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Abstract: | A novel harringtonolide-inspired scaffold containing a cycloheptatriene ring and two fused cyclopentane rings has been synthesised from simple starting materials. The scaffold, containing a similar substitution pattern and relative stereochemistry to the complex diterpenoid, has been enumerated into a small library of derivatives. One of these library members has been converted into a sub-library of substituted triazoles using copper-catalysed azide-alkyne cycloaddition (click) chemistry. The scaffold may be useful in drug discovery or in the preparation of additional molecular probes for chemical biology. |
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