Synthesis of novel isoxazole-benzoquinone hybrids via 1,3-dipolar cycloaddition reaction as key step |
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| Authors: | P Ravi Kumar Manoranjan BeheraK Raghavulu A Jaya ShreeSatyanarayana Yennam |
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| Institution: | a Department of Medicinal Chemistry, GVK Biosciences Pvt. Ltd., Plot No. 28, IDA, Nacharam, Hyderabad 500 076, AP, India
b Centre for Chemical Sciences & Technology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad 500 072, AP, India |
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| Abstract: | An efficient method for the preparation of novel 2-(5-arylisoxazol-3-yl)cyclohexa-2,5-diene-1,4-dione hybrids via 1,3-dipolar cycloaddition followed by an oxidation reaction using ceric ammonium nitrate (CAN) has been described. Using this method, various aryl as well as alkyl substituted isoxazole-benzoquinone hybrids were synthesized in high yields. |
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| Keywords: | Oxime Cycloaddition Hybrid molecule Isoxazole Benzoquinone Huisgen reaction |
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