The use of unsymmetrical indirect covariance NMR methods to obtain the equivalent of HSQC-NOESY data |
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Authors: | Blinov Kirill A Williams Antony J Hilton Bruce D Irish Patrick A Martin Gary E |
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Affiliation: | Advanced Chemistry Development, Moscow Department, 6 Akademik Bakulev Street, Moscow 117513, Russian Federation, Russia. |
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Abstract: | We have recently demonstrated that unsymmetrical indirect covariance NMR methods can be used to mathematically calculate the equivalent of low sensitivity, hyphenated NMR experiments by combining data from a pair of higher sensitivity experiments. The present report demonstrates the application of this method to the combination of HSQC and NOESY spectra to provide results comparable to HSQC-NOESY data, albeit with greater sensitivity and with considerably less spectrometer time. |
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