One-pot three-component Mannich-type reactions using Sulfamic acid catalyst under ultrasound irradiation |
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Authors: | Hongyao Zeng Hua Li Huawu Shao |
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Affiliation: | aNatural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, PR China;bGraduate School of Chinese Academy of Sciences, PR China |
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Abstract: | Sulfamic acid (NH2SO3H, SA) was used as an efficient, inexpensive, non-toxic and recyclable green catalyst for the ultrasound-assisted one-pot Mannich reaction of aldehydes with ketones and amines. This ultrasound protocol has advantages of high yield, mild condition, no environmental pollution, and simple work-up procedures. Most importantly, β-aminocarbonyl compounds with ortho-substituted aromatic amines are obtained in acceptable to good yields by this methodology for the first time. |
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Keywords: | Mannich reaction Ultrasound β -Aminocarbonyl compound One-pot reaction Sulfamic acid |
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