Preparation of N-aryl-ketonitrone spin traps |
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Authors: | Inas El Hassan Robert Lauricella Béatrice Tuccio |
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Institution: | (1) Laboratoire TRACES, Universités Aix-Marseille 1 et 3, 13397 Marseille, France |
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Abstract: | The syntheses of seven N-aryl-C,C-dialkoxycarbonylnitrones 1–7, six of which were original, were achieved from the appropriate aryl-nitroso compounds. These ketonitrones were found to
trap efficiently carbon-centred free radicals in aqueous media, yielding stable aminoxyl radicals whose EPR spectra lasted
several days. The two penta-deuterated compounds 6 and 7 were also found to be efficient at trapping methoxyl radical. Their various spin adducts showed simple three line signals,
very sensitive to the polarity of the environment. This study represents the very first use of linear ketonitrones as spin
traps. |
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Keywords: | Ketonitrones Spin trapping free radicals nitroxides EPR spectroscopy |
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