Synthesis of the pyrrolidinone core of KSM-2690 B |
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| Authors: | Donohoe Timothy J Chiu Jessica Y K Thomas Rhian E |
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| Institution: | Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, U.K. timothy.donohoe@chem.ox.ac.uk |
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| Abstract: | reaction: see text] The first synthesis of the pyrrolidinone core of the polyene beta-lactone antibiotic KSM-2690 B is described. An ammonia-free Birch reductive aldol reaction utilizing acetaldehyde is one of the key steps, together with a ruthenium-catalyzed alkene isomerization reaction. |
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