| 两种钒配合物的合成、表征及与Ct-DNA作用研究 |
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| 引用本文： | 周荫庄,冯静楠,岳蕾,屠淑洁,朱惠菊. 两种钒配合物的合成、表征及与Ct-DNA作用研究[J]. 化学学报, 2009, 67(12): 1297-1302 |
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| 作者姓名： | 周荫庄 冯静楠 岳蕾 屠淑洁 朱惠菊 |
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| 作者单位： | 首都师范大学化学系,北京,100048;首都师范大学化学系,北京,100048;首都师范大学化学系,北京,100048;首都师范大学化学系,北京,100048;首都师范大学化学系,北京,100048 |
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| 基金项目： | 北京市教育委员会科技发展计划面上 |
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| 摘 要： | 合成了两种钒-邻香草醛衍生物配合物[VO2(C10H11O3N)](HOCH2CH2NH3) (1)和VO(C8H8O3N)2 (2); 用FT-IR和X-ray单晶衍射对它们的晶体结构进行了表征; 用紫外吸收光谱法、荧光光谱法、循环伏安法、粘度法等分析了两种配合物与小牛胸腺DNA (Ct-DNA)的作用; 结果表明配合物1以非插入方式与Ct-DNA作用, 配合物2则以插入方式与Ct-DNA作用.
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| 关 键 词： | 钒 邻香草醛 配合物 嵌插作用 小牛胸腺DNA |
| 收稿时间： | 2008-07-16 |
| 修稿时间： | 2008-12-05 |
Synthesis, Characterization and Ct-DNA Interaction Study of Two Vanadium Complexes |
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| Zhou Yinzhuang,Feng Jingnan,Yue Lei,Tu Shujie,Zhu Huiju. Synthesis, Characterization and Ct-DNA Interaction Study of Two Vanadium Complexes[J]. Acta Chimica Sinica, 2009, 67(12): 1297-1302 |
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| Authors: | Zhou Yinzhuang Feng Jingnan Yue Lei Tu Shujie Zhu Huiju |
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| Affiliation: | (Department of Chemistry, Capital Normal University, Beijing 100048) |
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| Abstract: | Two vanadium complexes with o-vanillin derivatives, [VO2(C10H11NO3)](HOCH2CH2NH3) (1) and VO(C8H8NO3)2 (2), were synthesized and characterized by FT-IR and single crystal X-ray diffraction analysis. The interaction of the two complexes with calf thymus-DNA (Ct-DNA) has been investigated by UV-Vis absorption spectroscopy, fluorescence spectroscopy, cyclic voltammetry and viscosity measurements. The results indicated that the complex 1 interacted with Ct-DNA in a non-intercalative mode, while complex 2 might be bonded to Ct-DNA through an intercalative mode. |
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| Keywords: | vanadium o-vanillin complex intercalation interaction calf thymus DNA |
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