| 双光子荧光有机纳米粒子的细胞染色 |
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| 引用本文： | 徐红,杨淑敏,陈更,田雷蕾,何凤,王广义,马於光.双光子荧光有机纳米粒子的细胞染色[J].高等学校化学学报,2010,31(4):632-634. |
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| 作者姓名： | 徐红 杨淑敏 陈更 田雷蕾 何凤 王广义 马於光 |
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| 作者单位： | 1. 吉林大学第一医院, 长春 130021;
2. 吉林大学超分子结构与材料国家重点实验室, 长春 130012 |
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| 摘 要： | 本文采用具有较大双光子吸收截面的有机分子2,5,2′,5′-(4′-N,N-二苯胺苯乙烯基)联苯(DPA-TSB)(双光子吸收截面δ: 3288 GM, 1 GM=1×10-50 cm4·s·photon-1·molecule-1), 通过再沉淀法制备水相分散的纳米粒子. 研究表明, 这种有机双光子纳米粒子可以有效地富集在细胞质中, 对细胞染色显示出良好的荧光成像能力.
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| 关 键 词： | 双光子荧光 有机纳米粒子 细胞染色 |
| 收稿时间： | 2009-10-04 |
Organic Two-photon Fluorescence Nanoparticles for Cell Stains |
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| XU Hong,YANG Shu-Min,CHEN Geng,TIAN Lei-Lei,HE Feng,WANG Guang-Yi,....Organic Two-photon Fluorescence Nanoparticles for Cell Stains[J].Chemical Research In Chinese Universities,2010,31(4):632-634. |
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| Authors: | XU Hong YANG Shu-Min CHEN Geng TIAN Lei-Lei HE Feng WANG Guang-Yi |
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| Institution: | 1. The First Hospital of Jilin University, Changchun 130021, China;
2. State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130012, China |
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| Abstract: | Two-photon absorption materials offer great promise as the new generation of fluorescent probes to image and study biological processes. We present water-dispersed two-photon functional organic nanoparticles which have been fabricated via reprecipitation method based on two-photon absorbing molecule 2,5,2′,5′-tetra(4′-N,N-diphenylaminostyryl)biphenyl(DPA-TSB), aiming to increase active dye loading density and enhance sensitive bioimaging in the microscopic level. In vitro confocal microscopy has demonstrated that these nanoparticles are avidly internalized into cells with bright fluorescence. The good cell membrane permeability of two-photon functional DPA-TSB nanoparticles make them use as bioimaging staining agent for the deeper tissue. |
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| Keywords: | Two-photon fluorescence Organic nanoparticle Cell stain |
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